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Ingredients:

Magnesium Citrate
J Am Coll Nutr. 1990 Feb;9(1):48-55)(Clin Biochem Rev. 2003 May; 24(2): 47–66.
Clin Biochem Rev. 2003 May; 24(2): 47–66.
Nutrients. 2015 Sep; 7(9): 8199–8226.
J Res Med Sci. 2012 Dec; 17(12): 1161–1169.
http://www.drweil.com/drw/u/ART02805/magnesium.html
Acta Anaesthesiol Taiwan. 2016 Jul 16. pii: S1875-4597(15)30016-3.

L-Theanine as L-TeaActive(TM)
Green tea contains L-theanine, an amino acid that has anxiety-reducing properties. When paired with the caffeine that's also in some green teas, L-theanine helps put you in a state of relaxed alertness. James Rouse and Debra Rouse, "Ask the Naturopaths,"Vegetarian Times, October 2006.ALPHAWAVES are the signals your brain gives off when you're feeling relaxed. Now a new supplement called l-theanine that's made from green tea can boost the number you produce. 'It takes 30-40 minutes to show effects, it's great if you're feeling anxious,' says Alice Bradshaw of supplement firm Solgar. 'Your LIFE: 21 New Ways to Be HAPPY; WELL-BEING as the Days Get Shorter and Nights Get Darker, Don't Despair. There Are Lots of Ways to Stay Bright All Winter,' The Mirror (London, England), October 26, 2007.Juneja LR. Suntheanine and its relaxation effect in humans. Trends in Food Science & Tech . 1999;10;199-204.* Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr . 2008;17 Suppl 1:167-168.Ritsner MS, Miodownik C, Ratner Y, et al. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study. J Clin Psychiatry . 2011;72(1):34-42. Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol . 2007;74(1):39-45.

L-Tryptophan
L-Tryptophan, the amino acid, gained favor in the 1980s for the treatment of insomnia because of its safety, affordability, and over-the-counter availability. This dietary supplement appeared to be helpful in correcting transient sleep disturbances by decreasing sleep latency and increasing total sleep time." Kathryn J. Zerbe, Women's Mental Health in Primary Care(Philadelphia, PA: W. B. Saunders, 1999), 174.Researchers say that L-tryptophan is converted to a brain chemical known as serotonin, which directly affects sleep. L-tryptophan can induce sleep or help people sleep longer." John Schieszer, "Does Turkey Make You Tired?," St Louis Post-Dispatch (MO), November 23, 1995.

Phenibut
CNS Drug Rev. 2001 Winter;7(4):471-81

Melatonin
http://www.webmd.com/sleep-disorders/tc/melatonin-overview#1
J Med Genet 2003;40:793-796
Clin Geriatr Med. 2008 Feb; 24(1): 121–viii.
Int J Geriatr Psychiatry. 2011 Jul;26(7):687-94.

Organic Ashwagandha Root Powder
Still others present popular Ayurvedic botanicals, such asashwagandha, Sida cordifoilia and Coleus forskohli, as 'alchemical energy-givers' and as 'critical for increasing resistance and energy.'93 'Energy' in fact seems to be the single most important appeal to the elderly Ayurvedic user. In this view, the inevitable process of aging and degeneration is somehow 'reversed' or 'kept at bay'" Sita Reddy, 'The Politics and Poetics of “magazine Medicine”,' in The Politics of Healing: Histories of Alternative Medicine in Twentieth-Century North America, ed. Robert D. Johnston (New York: Routledge, 2004).

Organic Hops
Acta Physiol Hung. 2012 Jun;99(2):133-9. doi: 10.1556/APhysiol.99.2012.2.6.

Organic Passion Flower Herb Powder
The uses here are based on tradition or scientific theories of Passiflora species. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. These traditional uses includes alcohol withdrawal, antibacterial, anti-seizure, anti-spasm, aphrodisiac, asthma, attention deficit hyperactivity disorder (ADHD), burns (skin), cancer, chronic pain, cough, drug addiction, Epstein-Barr virus, fungal infections, gastrointestinal discomfort (nervous stomach), Helicobacter pylori infection, hemorrhoids, high blood pressure, menopausal symptoms (hot flashes), nerve pain, pain (general), skin inflammation, tension and wrinkle prevention (Dhawan et al., 2002).A. Dhawan K, Kumar S, Sharma A (2002). Reversal of cannabinoids (delta9-THC) by the benzoflavone moiety from methanol extract of Passiflora incarnata Linneaus in mice: a possible therapy forcannabinoid addiction. J. Pharm. Pharmacol., 54(6): 875-881.Dhawan K, Kumar S, Sharma A (2002). Suppression of alcohol cessation oriented hyperanxiety by the benzoflavone moiety of Passiflora incarnata Linneaus in mice. J. Ethnopharmacol., 8(1-2): 239-244
Lavoisier Publishing, Paris.Hawaii Edu Study - Passion Flower, Skullcap, Lemon Balm, Valerian, Chamomile
Passion flower (P. incarnata) is used for the cure of nervous restlessness, sleep disorders, restlessness, nervous stress and anxiety (Bergne, 1995; Bruneton, 1995; Bradley, 1992). A. Bergne P (1995). Passion flower. Med. Herbalism, 7: 14- 26.
B. Bruneton J (1995). Pharmacognosy, Photochemistry, Medicinal Plants. C. Bradley PR (1992). British Herbal Compendium. Bournemouth, BritishHerbal Medicine Association, p. 1.

Organic Wild Lettuce
J Ethnopharmacol. 2006 Sep 19;107(2):254-8.

Organic Valerian Root Powder
Valerian has been used as a medicinal herb since at least the time of ancient Greece and Rome. Its therapeutic uses were described by Hippocrates, and in the 2nd century, Galenprescribed valerian for insomnia. Blumenthal M, Goldberg A, Brinckmann J, eds.: Valerian root. In: Herbal Medicine: Expanded Commission E Monographs. Newton, MA: Integrative Medicine Communications, 2000: 394-400.
Turner W: Of Valerianae. In: Chapman GTL, McCombie F, Wesencraft A, eds. A New Herbal, Parts II and III. Cambridge: Cambridge University Press, 1995: 464-466, 499-500, 764-765. [Republication of parts II and III of A New Herbal, by William Turner, originally published in 1562 and 1568, respectively.]In the 16th century, Valerian was used to treat nervousness, trembling, headaches, and heart palpitations. Culpeper N: Garden valerian. In: Culpeper's Complete Herbal. New York: W. Foulsham, 1994: 295-297. [Republication of The English Physitian, by Nicholas Culpeper, originally published in 1652.]During World War II, it was used in England to relieve the stress of air raids.Grieve M: Valerian. In: A Modern Herbal. New York: Hafner Press, 1974: 824-830.
A study of valerian examined long-term effects in 121 participants with documented nonorganic insomnia[. Participants received either 600 mg of a standardized commercial preparation of dried valerian root (LI 156, Sedonium?*) or placebo for 28 days. Several assessment tools were used to evaluate the effectiveness andtolerance of the interventions, including questionnaires on therapeutic effect (given on days 14 and 28), change in sleep patterns (given on day 28), and changes in sleep quality and well-being (given on days 0, 14, and 28). After 28 days, the group receiving the valerian extract showed a decrease in insomnia symptoms on all the assessment tools compared with the placebo group. The differences in improvement between valerian and placebo increased between the assessments done on days 14 and 28.Vorbach EU, Gortelmeyer R, Bruning J: Treatment of insomnia: effectiveness and tolerance of a valerian extract [in German]. Psychopharmakotherapie 3: 109-115, 1996.

Warnings: As with any supplement, if you are taking medication or have a medical condition, consult your doctor before use. Not formulated for use by children or those pregnant or lactating. Do not exceed recommended use. May cause drowsiness, do not operate machinery. Keep out of reach of children.



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