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CalmSupport only uses bioactive versions of vitamins which do not need to be metabolized by your body, allowing for easier digestion, faster absorption to provide the maximum benefit.  We also use the finest organic herbal powder rather than extracts in order to give you the full benefit that each specific herb provides. We pride ourselves by offering the highest quality ingredients in our amazing supplement.

Herbs:

Organic Ashwagandha Root Powder – Also known as ‘Indian Ginseng,’ Ashwagandha has been used in India for centuries to help improve energy levels as well as help with insomnia. Modern studies have shown evidence to support these traditional uses[1][2].

Organic Ginger Root Powder – Ginger has shown to be an effective remedy for the nausea associated with motion sickness. It is also an anti-inflammatory and is a powerful natural painkiller. Research has shown that ginger may provide headache relief due to its ability to stop prostaglandins from causing pain and inflammation in blood vessels[3][4].

Organic Motherwort Herb Powder – Calming herb helpful for combating irritability and emotional volatility. Motherwort can relieve heart palpitations and reduce hypertension caused by anxiety[5].

Organic Oat Seed Powder – Milky oats have been used historically for reducing acute and chronic anxiety[6]. Extracts of milky oats have been shown to improve cognitive function[7].

Organic Passion Flower Herb Powder – Many people find Passionflower a soothing sleep-aid and in supporting relaxation in times of stress. Scientists believe that passionflower works by increasing levels of a chemical called gamma-aminobutyric acid (GABA) in the brain[8]. GABA reduces the activity of some brain cells, inducing a greater state of relaxation[9].

Organic Phyllanthus (Bhumyamalaki) Herb Powder – Bhumyamalaki (Phyllanthus amarus is an herb from India with historical use benefitting the liver[10]. Modern reseatch has shown extracts of Bhumyamalaki to include antiviral, antibacterial, antiplasmodial, anti-inflammatory, antimalarial, antimicrobial, anticancer, antidiabetic, hypolipidemic, antioxidant, hepatoprotective nephroprotective and diurectic properties[11].

Organic Velvet Bean Seed Powder – Also known as Mucuna Pruriens. Contains L-Dopa, which is a precursor to the neurotransmitter Dopamine.  Dopamine is a main reward neurotransmitter that is released when people take narcotics and is responsible for much of their addictive potential[12]. Taking Mucuna, however, has been shown to naturally increase dopamine levels[13]. One study also showed reduced stress levels in those taking Mucuna[14].

Organic Valerian Root Powder – Valerian has been used for thousands of years around the world to treat several disorders including restlessness, nervousness and insomnia[15][16][17]. For many people it helps fight anxiety, nervousness, lowers heart rate which relieves hypertension. In WWII Valerian root was used in England to reduce the stress of air raids[18].


Amino acids:
 

GABA (gamma-aminobutyric acid) – GABA is a chemical that is made in the brain. It is taken by mouth for relieving anxiety, improving mood, reducing symptoms of premenstrual syndrome (PMS), and treating attention deficit hyperactivity disorder (ADHD). GABA has been shown to act as a natural relaxant and improve anxiety[19].

L-Theanine as L-TeaActive (TM) – L-Theanine as L-TeaActive(TM) is an amino acid found in green tea and has been shown to have a direct influence on brain activity, such as reducing stress[20]. It has also been shown to have positive effects on anxiety in patients with schizophrenia[21].

L-Tryptophan – Tryptophan is an important amino acid that is converted to 5-HTP (5-hyrdoxytryptophan) and then to Serotonin in the body.  Serotonin transmits signals between nerve cells and improves mood. Low serotonin levels are implicated in depression[22]. Tryptophan levels have been shown to be lower in those suffering from insomnia[23]. Tryptophan intake has been associated with lower levels of depression and improved sleep[24].


Vitamins:

Folic Acid – Folic acid deficiency has been found among people with depression and has been linked to poor response to antidepressant treatment. Some study suggests that folic acid supplementation might decrease systolic blood pressure and improve flow-mediated dilation. Folic acid deficiency will occur if the body does not get the adequate amount of folic acid from dietary intake. Folic acid has been shown to be effective in the treatment of megaloblastic and macrocytic anemias due to folate deficiency[25][26][27].

Thiamin (as Thiamine HCL) – Thiamin aids the central nervous system. Poor dietary intake can lead to thiamin deficiency which can cause lesions of nerves, general debility, and painful rigidity. It is also essential for the functioning of the heart and muscles[28][29][30].

Vitamin B6 (as Pyridoxal-5-Phosphate) – Pyridoxine, also known as Vitamin B6, is necessary for the transformation and utilization of amino acids for many functions in the body, including energy production and neurotransmitter synthesis. Vitamin B6 is essential for the production of the neurotransmitter serotonin in the brain. Vitamin B6 is also involved in the production of hemoglobin, intrinsic factor, and is a vital component in the formation of the myelin sheath that surrounds nerve cells. In order for pyridoxine to be used by the body it must first be converted to its active form of pyridoxal 5'-phosphate (P5P), a process that takes place in the liver.[31][32][33].

Vitamin B12 (as Methylcobalamin) – Vitamin B12 is used for treating and preventing vitamin B12 deficiency, a condition in which vitamin B12 levels in the blood are too low. Many people with depression have been found to have low B12 levels. Vitamin B12 may benefit memory loss, Alzheimer’s disease, boosting mood, improving energy, improving concentration, increased immune system function, and slowing brain aging[34][35][36].

Vitamin C (as Ascorbic Acid) – Vitamin C is essential for life. It is an extremely important antioxidant that protects tissues from damage and improves quality of connective tissue[37].


Minerals:

Zinc (as Zinc Citrate) – Zinc is a metal that is considered an “essential trace element” because very small amounts of zinc are necessary for human health. Zinc is used for treatment and prevention of zinc deficiency and its consequences, including stunted growth and acute diarrhea, and slow wound healing. It is used for boosting the immune system, production of antibodies, T-cells and other blood cell activity[40][41][42][43].


Sources:

[1] Mol Cell Biochem. 2017 Mar;427(1-2):91-101. doi: 10.1007/s11010-016-2900-1

[2] Cell Mol Life Sci. 2015 Dec;72(23):4445-60. doi: 10.1007/s00018-015-2012-1.

[3] Blumenthal M, Goldberg A, Brinckman J, eds. Herbal Medicine: Expanded Commission E Monographs.

[4] Coates P, Blackman M, Cragg G, et al., eds. Encyclopedia of Dietary Supplements. New York, NY: Marcel Dekker; 2005:241–248.

[5] John G. Howells and M. Livia Osborn, A Reference Companion to the History of Abnormal Psychology, vol. 2 (Westport, CT: Greenwood Press, 1984), 651.

[6] Abascal K., Yarnell E. Nervine herbs for treating anxiety. Altern. Complement. Ther. 2004;10:309–315

[7] J. Altern. Complement. Med. 2010;17:635–637.

[8] J. Ethnopharmacol., 8(1-2): 239-244

[9] Fitoterapia. 2001 Dec;72(8):922-6.

[10] Aacharya Vaidya Jadavaji Trikamji., editor. Varanasi: Chaukhamba Sanskrit sansthan. 2nd ed. 47. Vol. 4. Varanasi: Chaukhamba Sanskrit sansthan; 1990.

[11] J Ethnopharmacol. 2011 Nov 18;138(2):286-313. doi: 10.1016/j.jep.2011.09.040.

[12] Arch Neurol. 2007 Nov;64(11):1575-9.

[13] Fertil Steril. 2009 Dec;92(6):1934-40. doi: 10.1016/j.fertnstert.2008.09.045.

[14] Evid Based Complement Alternat Med. 2010 Mar;7(1):137-44. doi: 10.1093/ecam/nem171.

[15] Blumenthal M, Goldberg A, Brinckmann J. Herbal Medicine: Expanded Commission E Monographs. Newton, MA: Integrative Medicine Communications; 2000:394-400.

[16] Balderer G, Borbely AA. Effect of valerian on human sleep. Psychopharmacology (Berl). 1985;87(4):406-409.

[17] Vorbach EU, Gortelmeyer R, Bruning J: Treatment of insomnia: effectiveness and tolerance of a valerian extract [in German]. Psychopharmakotherapie 3: 109-115, 1996.

[18] Turner W: Of Valerianae. In: Chapman GTL, McCombie F, Wesencraft A, eds. A New Herbal, Parts II and III. Cambridge: Cambridge University Press, 1995: 464-466, 499-500, 764-765.

[19] Biofactors. 2006;26(3):201-8.

[20] Trends in Food Science & Tech . 1999;10;199-204.* Nobre AC, Rao A, Owen GN.

[21] J Clin Psychiatry . 2011;72(1):34-42.

[22] Pharmacol Biochem Behav. 2002 Apr;71(4):857-65.

[23] Pak J Pharm Sci. 2017 Jul;30(4(Suppl.)):1431-1438.

[24] J Nutr. 2016 Dec;146(12):2609S-2615S.

[25] J Psychopharmacol. 2005 Jan;19(1):59-65

[26] Arch Latinoam Nutr. 2005 Jun;55(2):118-23

[27] Arch Gerontol Geriatr. 2015 Mar-Apr;60(2):344-8. doi: 10.1016/j.archger.2015.01.001.

[28] Brody T. Nutritional Biochemistry. 2nd ed. San Diego: Academic Press; 1999.

[29] Tanphaichitr V. Thiamin. In: Shils M, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore: Williams & Wilkins; 1999:381-389

[30] Rindi G. Thiamin. In: Ziegler EE, Filer LJ, eds. Present Knowledge in Nutrition. 7th ed. Washington D.C.: ILSI Press; 1996:160-166.

[31] Brody T. Nutritional Biochemistry. 2nd ed. San Diego: Academic Press; 1999.

[32] Arthritis Res Ther. 2005;7(6):R1404-11. Epub 2005 Oct 14.

[33] Pak J Pharm Sci. 2013 Sep;26(5):1057-69.

[34] J Psychopharmacol. 2005 Jan;19(1):59-65

[35] Nutr Rev. 2010 Dec;68 Suppl 2:S112-8. doi: 10.1111/j.1753-4887.2010.00346.x.

[36] Am J Clin Nutr. 2016 Apr;103(4):1045-54. doi: 10.3945/ajcn.115.116970.

[37] J Am Coll Nutr. 2003 Feb;22(1):18-35.

[40] Metallomics. 2014 Jul;6(7):1175-80. doi: 10.1039/c3mt00353a.

[41] Age (Dordr). 2013 Jun;35(3):839-60. doi: 10.1007/s11357-011-9377-3.

[42] Nutrients. 2017 Dec 24;10(1). pii: E16. doi: 10.3390/nu10010016.

[43] Nutrients. 2017 Nov 25;9(12). pii: E1286. doi: 10.3390/nu9121286.

CalmSupport does not use Magnesium Stearate as a flow agent. (A flow agent is a substance that is used during the manufacturing process to help prevent the ingredients and capsules from sticking together.) There has been some controversy about the use of Magnesium Stearate in supplements and vitamins.  A study published in the Journal of Pharmaceutical Sciences found that drugs lubricated with Magnesium Stearate exhibited a decrease in dissolution rate compared to those lubricated with Sodium Stearyl Fumarate (A water-based compound).  The results suggest that Magnesium Stearate could possibly decrease the nutrient absorption rate of a dietary supplement. http://www.ncbi.nlm.nih.gov/pubmed/3735097. We have decided not to use Magnesium Stearate in CalmSupport. Instead we use Organic Rice Hull Powder as a flow agent. We highly suggest that you do research before using any product that has Magnesium Stearate as an ingredient.

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